LIVER CIRRHOSIS: STRUCTURAL AND FUNCTIONAL CHANGES – A SCIENTIFIC REVIEW

Abstract

Liver cirrhosis is a chronic, progressive disease characterized by extensive fibrosis and the formation of regenerative nodules, which leads to significant alteration of liver structure and function. This article presents a detailed scientific analysis of the histological, vascular, and functional changes that occur in cirrhotic liver tissue. The structural remodeling of hepatic lobules and vascular architecture is strongly associated with impaired metabolic, synthetic, and detoxification functions of the liver. Understanding these changes is crucial for effective diagnosis, management, and research in hepatology.