COMPARATIVE ANALYSIS OF INFUSION THERAPY AND COMPLEX INTENSIVE THERAPY AFTER NEURO-ONCOLOGICAL SURGERY

Abstract

ABSTRACT. Neurooncological diseases represent one of the most complex clinical conditions, characterized by high mortality and disability rates. Although brain tumors account for only 1.5–2% of all cancers, their impact on functional and vital prognosis is substantial. Aim. To study the dynamics of cerebral blood flow and intracranial pressure (ICP) in patients undergoing neurooncological surgery and to evaluate the effectiveness of standard resuscitation protocols. Materials and Methods. A prospective observational study conducted at Samarkand State Medical University from 2023–2025 included 53 patients aged 18–73 years. Surgical approaches included craniotomy, stereotactic, and debulking resections. Resuscitation protocols incorporated sedation with propofol, midazolam, and dexmedetomidine; ventilation; and osmotherapy. Results. The study results demonstrated that perioperative ICP and hemodynamic parameters are directly dependent on the invasiveness of the surgery and the selected therapy. Propofol provided the most stable ICP reduction, hyperventilation resulted in short-term effects with increased ischemic risk, and combined osmotherapy offered the most effective pressure control.