ENHANCING THE BIOAVAILABILITY OF SOLID DOSAGE FORMS USING NANOTECHNOLOGY

Abstract

In modern pharmacy, solid dosage forms are among the most widely used types of medicines. However, due to the poor water solubility and low bioavailability of many active pharmaceutical ingredients, their therapeutic efficacy is often insufficiently manifested. This issue is particularly evident in substances classified as Class II and IV according to the Biopharmaceutics Classification System (BCS). In recent years, the introduction of nanotechnologies into the field of pharmacy has gained particular importance as one of the promising approaches to addressing this problem.

This article analyzes the role of drug delivery systems developed based on nanotechnologies in enhancing bioavailability in solid dosage forms. The effects of nanoformulations, such as nanoparticles, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and nanoemulsions, on the solubility, absorption, and biological availability of active substances are considered. In addition, technological aspects and advantages arising when converting nano-based systems into tablet and capsule forms are highlighted. The analysis results confirm that solid dosage forms created using nanotechnologies significantly increase the bioavailability of active substances, improve dosing accuracy, and reduce the risk of adverse effects. This approach can be regarded as an effective and promising direction for the modern pharmaceutical industry