ANALYSIS OF MORPHO-FUNCTIONAL CHANGES IN THE HEART IN EXPERIMENTAL MYCOBACTERIAL LUNG DAMAGE
Keywords:
mycobacteria, pulmonary tuberculosis, cardiac morphology, myocardium, hypoxia, pulmonary hypertension, right ventricular hypertrophy, interstitial fibrosis, experimental study.Abstract
This study is devoted to a comparative analysis of morphological changes in cardiac tissue under conditions of experimental mycobacterial lung injury caused by Mycobacterium tuberculosis. The investigation was conducted using a laboratory animal model, in which histological and morphometric methods were applied to assess structural and morphofunctional remodeling of the myocardium during chronic pulmonary inflammation. It was established that mycobacterial lung damage is accompanied by the development of chronic hypoxia, systemic intoxication, and pulmonary hypertension, leading to dystrophic, microcirculatory, compensatory-hypertrophic, and fibrotic changes in the myocardium. The most pronounced alterations were observed in the right ventricle and were characterized by myocardial hypertrophy and the formation of interstitial fibrosis. The obtained data expand current understanding of the pathogenetic mechanisms underlying secondary cardiac involvement in pulmonary tuberculosis.
