EARLY CLINICAL-PATHOGENETIC MARKERS OF DIABETES MELLITUS AND MULTI-LEVEL PREVENTION STRATEGIES, FUNDAMENTAL AND PRACTICAL ANALYSIS
Keywords:
Diabetes mellitus, insulin resistance, glycated hemoglobin, prediabetes, metabolic syndrome, beta-cell apoptosis, prevention, healthy lifestyle, Uzbekistan healthcare system, dyslipidemia, glucose tolerance, visceral obesity.Abstract
This comprehensive research work is dedicated to studying the formation mechanisms, early diagnostic opportunities, and preventive measures of type 2 diabetes mellitus (T2DM)—one of the most pressing global problems of modern medicine. The article analyzes the impact of insulin resistance on intracellular signaling systems, changes in metabolic homeostasis in prediabetic states, and the dynamics of the disease's spread among the population of Uzbekistan. Furthermore, the effectiveness of modern screening methods, the diagnostic significance of the glycated hemoglobin (HbA1c) test, and scientifically based algorithms for reducing risk through lifestyle modification are detailed. The results of the research are aimed at preventing severe complications (nephropathy, retinopathy, neuropathy) through early diagnosis and include practical recommendations for primary care physicians.
