REMEDIAL OF NON-SPECIFIC REACTIVITY INDICATORS IN MINI-PIGS WITH EXPERIMENTAL OBSTRUCTIVE JAUNDICE

Abstract

The minipig, a porcine model, has garnered increasing interest in pharmaceutical research and development as a non-rodent in vivo model for toxicological evaluation (Bode et al. Citation2010; Ganderup et al. Citation2012), formulation advancement (Henze et al. Citation2019), and pharmacokinetic (PK) modelling that aids in predicting human PK (Yoshimatsu et al. Citation2016; Ding et al.The minipig, a porcine model, has garnered increasing interest in pharmaceutical research and development as a non-rodent in vivo model for toxicological evaluation (Bode et al. Citation2010; Ganderup et al. Citation2012), formulation advancement (Henze et al. Citation2019), and pharmacokinetic (PK) modelling that aids in predicting human PK (Yoshimatsu et al. Citation2016; Ding et al.