A NEW APPROACH TO THE MORPHOLOGICAL CHANGES OF THE PANCREAS IN MYCOBACTERIAL INFECTION OF THE LUNG
Keywords:
Mycobacterial infection, pulmonary tuberculosis, pancreas, morphology, histopathology, microcirculation, acinar dystrophy, islets of Langerhans, systemic inflammation.Abstract
Mycobacterial infection of the lung induces systemic inflammatory, hypoxic, and токсико-иммунные responses that extend beyond pulmonary tissue. This review proposes a novel integrative approach to understanding morphological alterations of the pancreas during pulmonary mycobacterial infection. By synthesizing data from experimental and clinicopathological studies, we analyze structural remodeling of the exocrine and endocrine compartments, stromal reorganization, and microvascular pathology. Particular emphasis is placed on the interplay between hypoxia-induced injury, cytokine-mediated damage, and microangiopathy. Evidence suggests that pancreatic alterations represent a secondary systemic manifestation characterized by acinar dystrophy, islet remodeling, vascular disturbances, and progressive interstitial fibrosis. The proposed framework integrates morphometric, histopathological, and pathogenetic perspectives to clarify mechanisms of pancreatic involvement in pulmonary tuberculosis.
