MORPHOLOGICAL CHANGES IN THE MICROCIRCULATORY BED OF THE COLON UNDER CHRONIC CARBON MONOXIDE EXPOSURE
Keywords:
carbon monoxide, colon, microcirculation, capillaries, endothelium, hypoxia, vascular morphology, hemomicrocirculatory bed.Abstract
This study investigates morphological alterations in the microcirculatory bed of the colon under conditions of chronic carbon monoxide (CO) exposure. Special attention was paid to structural changes in arterioles, capillaries, venules, and hemomicrocirculatory exchange vessels. Histological analysis revealed vascular dilation, endothelial swelling, perivascular edema, stasis, erythrocyte aggregation, and thickening of the vascular wall. In prolonged exposure, destructive changes in endothelial cells, narrowing of capillary lumens, and signs of microthrombosis were observed. These alterations indicate severe impairment of tissue perfusion and development of chronic hypoxia. The obtained data demonstrate that chronic CO intoxication leads to progressive microcirculatory disorders that play a key role in trophic and functional damage of the colonic wall.
