POTENTIAL ROLE OF THE BCL2 938 C>A PROMOTER POLYMORPHISM IN CHRONIC MYELOPROLIFERATIVE NEOPLASMS: A HYPOTHESIS DRIVEN REVIEW

Authors

  • Jakhonov Azizbek Kholmirzaevich Author
  • Matkarimova Dilfuza Saburovna Author

Keywords:

chronic myeloproliferative neoplasm, BCL2, promoter polymorphism, –938 C>A, apoptosis regulation, genetic modifier

Abstract

Background: Chronic myeloproliferative neoplasms (CMPNs) are clonal hematopoietic stem cell disorders characterized by dysregulated proliferation, altered apoptosis, and inflammatory interactions. The BCL2 gene encodes an anti‑apoptotic protein that plays a key role in cell survival. A promoter single nucleotide polymorphism (SNP) at position –938 (C>A, known as rs2279115) in the BCL2 gene has been studied as a modulator of BCL2 expression, cancer risk, and prognosis in several malignancies. However, its significance in CMPNs is unknown.

Author Biographies

  • Jakhonov Azizbek Kholmirzaevich

    (Tashkent State Medical University, ALFRAGANUS UNIVERSITY)

     

  • Matkarimova Dilfuza Saburovna

    (Tashkent State Medical University)

     

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Published

2025-10-07

Issue

Vol. 35 No. 1 (2025): Modern education and development

Section

Articles