MORPHOLOGICAL EXAMINATION METHODS OF TISSUE MATERIAL OBTAINED FROM SURGERY FOR OTOSCLEROSIS
Keywords:
otosclerosis, stapedotomy, stapedectomy, morphological examination, histology, immunohistochemistry, electron microscopy, SEM, micro-CT, stapes footplate.Abstract
Otosclerosis is a pathological remodeling process of the endochondral bone of the inner ear capsule, often manifesting as fixation of the stapes footplate and conductive or mixed-type hearing loss. Clinical otosclerosis is more common in early adulthood, is noted relatively more frequently in women, and familial cases and bilateral involvement are observed in many cohorts. Surgical treatment, particularly stapedotomy and in some cases stapedectomy, allows not only for functional rehabilitation but also for the acquisition of tissue material for morphological analysis. Current literature indicates that the stapes suprastructure, footplate fragments, and, less commonly, larger otic capsule samples are important sources for morphological evaluation.
