SPECIFIC FEATURES OF DRUG-RESISTANT EPILEPSY ACROSS DIFFERENT AGE GROUPS
Keywords:
drug-resistant epilepsy, pharmacoresistance, age-related features, pediatric epilepsy, geriatric epilepsy, antiepileptic drugs, seizure control, neurodevelopment, polytherapy, clinical semiology.Abstract
This article examines the clinical and pathophysiological characteristics of drug-resistant epilepsy in various age categories, ranging from infancy to elderly patients. The phenomenon of pharmacoresistance remains one of the most challenging aspects of modern neurology, with its manifestations and underlying mechanisms significantly differing depending on the patient's age. In pediatric populations, drug resistance is often associated with structural brain abnormalities, genetic syndromes, and metabolic disorders, which require early intervention to prevent irreversible neurodevelopmental delays. In contrast, pharmacoresistance in adults and the elderly is frequently linked to acquired factors such as cerebrovascular diseases, post-traumatic changes, or neurodegenerative processes.
