EVALUATION OF THE EFFECTIVENESS OF DIAGNOSTIC METHODS (EEG AND MRI) IN PHARMACORESISTANT EPILEPSY
Keywords:
pharmacoresistent epilepsy, EEG, MRI, neuroimaging, epileptogenic zone, seizure monitoring, focal cortical dysplasia, diagnostic sensitivity, multimodal imaging, refractory epilepsy.Abstract
This article evaluates the diagnostic value and clinical effectiveness of Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI) in the management of drug-resistant epilepsy. Despite advancements in neuroimaging, identifying the exact epileptogenic zone remains a primary challenge for patients who fail to respond to standard antiepileptic therapy. The study analyzes the sensitivity and specificity of video-EEG monitoring in capturing interictal and ictal activity, as well as the role of high-resolution MRI (3T and 7T) in detecting subtle structural lesions such as focal cortical dysplasia and hippocampal sclerosis.
The integration of these diagnostic modalities is examined to determine their combined impact on localized seizure focus identification and subsequent surgical planning. The findings highlight that while EEG provides essential functional data regarding the electrical onset of seizures, MRI offers the necessary anatomical context to confirm structural triggers. The article concludes that a multimodal diagnostic approach is superior to either method alone, significantly increasing the success rate of therapeutic interventions and improving long-term outcomes for patients with refractory epilepsy.
