RESEARCH ON THE SYNTHESIS OF ACETYLENE-COLCHAMINE DERIVATIVES

Abstract

This article highlights the scientific foundations and practical solutions for the synthesis of colchamine acetylene derivatives. The aim of the study is to introduce an alkyne fragment into the colchamine molecule through the selective functionalization of reactive centers, resulting in a series of new derivatives suitable for studying the dependence of subsequent structural activity. Approaches of selective derivation of colchamine by O and N centers, introduction of propargyl group by esterification and carbamate, as well as addition of copper catalyst were used as the methodology. The scientific novelty is to substantiate the possibility of achieving high chemical selectivity under favorable conditions, minimizing side reactions, and improving the synthesis module, taking into account the steric and electronic properties of the colchamine structure. The results obtained show that acetylene derivatives are a promising platform for further pharmaceutical modifications.