СLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF THROMBOCYTOPATHIES IN CHILDREN

Abstract

Thrombocytopathies represent a diverse spectrum of platelet function disorders that manifest with a normal or slightly reduced platelet count. In pediatric practice, these conditions remain underdiagnosed due to their variable clinical manifestations and the lack of awareness among clinicians. Recent advances in molecular genetics and platelet function assays have considerably improved the diagnostic precision of thrombocytopathies. This study analyzes the clinical and morphological characteristics of thrombocytopathies in children and evaluates current diagnostic and therapeutic strategies. The novelty of this work lies in emphasizing the integration of next-generation sequencing (NGS), flow cytometry, and platelet ultrastructural analysis to differentiate inherited and acquired forms, allowing for personalized management approaches.