QALQONSIMON BEZ FAOLIYATIGA SALBIY TA’SIR KO‘RSATUVCHI KIMYOVIY BIRIKMALARNING KLINIK TAHLILI.
Keywords:
Qalqonsimon bez, tashqi muhit, yod, tiroksin, tireodit, treotoksikoz, gormonal buzilishlar, endokrin buzuvchi moddalar, PCB, bisfenol-A, ftalatlar, pestitsidlar, perfluor birikmalar, TTG.Abstract
Qalqonsimon bez inson organizmining o’sish va rivojlanishiga asosiy tasir ko’rsatuvchi a’zodir. Hozirgi globallashuv davrida qalqonsimon bez faoliyatiga ta’sir ko‘rsatuvchi ekzogen kelib chiqishli kimyoviy moddalarning, ya’ni endokrin buzuvchi moddalar (Endocrine Disrupting Chemicals, EDCs) ning organizmga, xususan, gormonal tizimga bo‘lgan salbiy ta’siri ilmiy asosda tahlil qilinadi. Ilmiy tadqiqotda eng ko‘p uchraydigan sanoat kimyoviy birikmalari — polixlorli bifenillar (PCB), polibromli difenil efirlar (PBDE), perxlorat, bisfenol-A, ftalatlar, pestitsidlar va perfluor birikmalarning qalqonsimon bez faoliyatiga ta’siri klinik, eksperimental va epidemiologik tadqiqotlar asosida tizimli ravishda yoritiladi. Shuningdek, ularning gormonal muvozanatdagi o‘zgarishlarga olib keluvchi toksikologik va molekulyar mexanizmlari tahlil qilinadi hamda sog‘liq uchun xavflilik darajasi baholanadi.
References
1. Diamanti-Kandarakis, E., et al. (2009). Endocrine-disrupting chemicals: An Endocrine Society scientific statement. Endocrine Reviews, 30(4), 293–342.
2. .Abdelouahab, N., et al. (2013). Maternal and cord-blood thyroid hormone levels and exposure to PBDEs and PCBs. American Journal of Epidemiology, 178(5), 701–713.
3. .Blount, B.C., et al. (2006). Urinary perchlorate and thyroid hormone levels. Environmental Health Perspectives, 114(12), 1865–1871.
4. .Vuong, A.M., et al. (2015). Maternal PBDE exposure and thyroid hormones: The HOME Study. Environmental Health Perspectives, 123(10), 1079–1085.
5. .Freire, C., et al. (2011). Association of OC pesticides with thyroid hormones. Environmental Research, 111(8), 1329–1338.
6. .Ballesteros, V., et al. (2017). Exposure to PFAS and thyroid function. Environmental International, 104, 61–69.
7. Olimjonovna, K. O. (2023). Ayollarda reproduktiv tizim faoliyatining a. O’zgarishida gipoterioz bilan birga kechishi. Ta'lim innovatsiyasi va integratsiyasi, 10(3), 174-179.
8. Olimjonovna, K. O. (2024). Hypothyroidism and reproductive dysfunction in women. Образование наука и инновационные идеи в мире, 36(5), 75-82.
9. Toxirovna, E. G. (2024). QALQONSIMON BEZ KASALLIKLARIDAN HASHIMOTO TIREODIT KASALLIGINING MORFOFUNKSIONAL O’ZIGA XOSLIGI. Modern education anddevelopment, 16(7), 120-135.
10. Ergasheva, G. T. (2024). THE SPECIFICITY OFAUTOIMMUNE THYROIDITIS IN PREGNANCY. European Journal of Modern Medicine and Practice, 4(11), 448-453.
11. Эргашева, Г. Т. (2024). ИССЛЕДОВАНИЕ ФУНКЦИИ ЩИТОВИДНОЙ ЖЕЛЕЗЫ ПРИ ТИРЕОИДИТЕ ХАШИМОТО. Modern education and development, 16(7), 106- 119.
12. Халимова, Ю. С., & Шокиров, Б. С. (2022). МОРФОФУНКЦИОНАЛЬНЫЕ ООБЕННОСТИ ВНУТРЕННИХ ОРГАНОВ ПРИ ХРОНИЧЕСКОМ АЛКОГОЛИЗМЕ. Scientific progress, 3(2), 782-789.
13. Halimova, Y. S. (2023). Morphofunctional Aspects of Internal Organs in Chronic Alcoholism. AMALIY VA TIBBIYOT FANLARI ILMIY JURNALI, 2(5), 83-87.
14. Khalimova, Y. S. BS Shokirov Morphological changes of internal organs in chronic alcoholism. Middle European scientific bulletin, 12-2021.
15. Kasatkina E.P. 1997; Gerasimov G.A. ; 2003; Bernal J, Nunez J., 1995; Chan S., Kilby J.00.
16. Vereshchagina GV 1991. Kandror VI 1999. Gerasimov GA 2003.
17. Khaskin VV 1975. Rossomakhin YuP, Pevny SA, 1991; LebonV. 2001.
18. Dedov I.I.Kas.19.19.P. Selyatitskaya V.G., Sviridenko G.A., 1999; Shcheplyagina L.A., 1998. Yod tanqisligi sharoitida bez yetarli darajada batafsil o‘rganilgan To‘raqulov Ya.X., 1979; Tepperman J., Tepperman H., 1989; Kasatkina E.P.
19. Gerasimov G.A., Troshinaur, 2001. 2002; Mostbcck A 1998; Roti E., Uberti ED, 2001. 2000 Gerasimov G.A.
20. Krasnoperov R.A. va boshqalar. 1992; Dmitrieva N.I. va boshq., 1994; Rom-Bugoslavskaya va boshqalar, 1997; Selyatitskaya V.G.
