SYSTEMATIC REVIEW OF SCIENTIFIC LITERATURE: THE EFFECT OF HYALURONIC ACID COMPOUNDS IN THE COMPLEX TREATMENT OF GENERALIZED PERIODONTITIS
Keywords:
Hyaluronic acid is a disaccharide polymer belonging to the glycosaminoglycan family. Native hyaluronic acid, which constitutes a significant portion of the extracellular matrix, is found in human connective and epithelial tissues in a high molecular weight form (10^4 – 10^6) (8). It is a structural component of both unmineralized (gingival tissue, periodontal ligament) and mineralized (cementum, alveolar bone) tissues of the oral cavity (9).Abstract
Gingivitis and periodontitis, often grouped under the common term periodontal diseases, are persistent infections of the periodontal tissues associated with biofilms (1,3). Between 20 and 50 percent of people worldwide suffer from periodontal diseases, with severe periodontitis being one of the main causes of tooth loss (4). Surgical and conservative approaches are used to treat gingivitis and periodontitis (5,6).
A significant number of adjuvant medications have been proposed to improve the clinical course after primary treatment, used in combination with primary therapeutic approaches (7). These adjuvants include various anti-inflammatory, antibacterial, and antiseptic compounds, such as chlorhexidine and essential oils. Other substances that can contribute to tissue regeneration and repair include hyaluronic acid (HA) and enamel matrix proteins.
References
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