CORRECTION OF NON-SPECIFIC REACTIVITY INDICATORS IN EXPERIMENTAL OBSTRUCTIVE JAUNDICE IN MINI-PIGS
Keywords:
The study was conducted at the RyazSMU WetLab between November 2022 and February 2024, involving 25 laboratory mini-pigs. The animals were randomly divided into two groups: a Control Group ($n=12$) and a Comparison Group ($n=13$), which received the immunocorrective drug Aminodihydrophthalazindione sodium. The study consisted of three stages:Abstract
Hepatocellular insufficiency in obstructive jaundice significantly worsens the prognosis and increases the risk of adverse outcomes. Since the severity of hepatic dysfunction correlates with the degree of immunological impairment, optimizing post-operative immunocorrection remains a critical issue.
Aim: To investigate the state of non-specific reactivity following biliary decompression in an experimental model of obstructive jaundice in mini-pigs and to evaluate the effect of an immunomodulatory drug during the post-decompression period.
References
1. Vinnik YS, Yakimov SV, Teplyakova OV. Pathogenesis and diagnosis of liver failure in obstructive jaundice. Journal of Siberian Medical Sciences. 2021;4:12-25. (Russian sources should be transliterated if required by the journal).
2. Kurbonov KM, Nazirboev KR. Optimization of biliary decompression in the treatment of mechanical jaundice. Surgery of Uzbekistan. 2022;2(94):45-51.
3. Pavlov CH, Ivashkin VT, Shulpekova YO. Modern approaches to the assessment of liver fibrosis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(1):31-39.
4. Alper AT, Belen KY. Immunomodulatory effects of Aminodihydrophthalazindione sodium in clinical practice: A review. Journal of Clinical Immunology and Immunopathology. 2020;15(3):112-118.
5. Swindle MM, Makin A, Herron AJ, Clubb FJ, Frazier KS. Swine as models in biomedical research and training. Veterinary Pathology. 2012;49(2):344-356. doi:10.1177/0300985811402844.
6. Schmucker DL, Sanchez H. Liver regeneration and aging: a review. Mechanisms of Ageing and Development. 2021;194:111425. doi:10.1016/j.mad.2020.111425.
7. Turaev BS, Akhmedov AA. Experimental modeling of obstructive jaundice in mini-pigs: Morphological aspects. Samarkand Medical Journal. 2023;1(5):88-94.
8. Kuznetsov VA, Smirnov IV. The role of non-specific immunity in the development of hepatic encephalopathy. Experimental and Clinical Gastroenterology. 2022;198(2):56-62.
9. Galle PR, Forner A, Llovet JM, et al. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. Journal of Hepatology. 2018;69(1):182-236.
10. Popov AV. Immunological monitoring in post-decompression period of obstructive jaundice. Medical News of the North Caucasus. 2024;19(1):10-14.
