TYPE 3 DIABETES: THE MOLECULAR LINK BETWEEN INSULIN RESISTANCE AND NEURODEGENERATION
Keywords:
Type 3 diabetes, Alzheimer’s disease, brain insulin resistance, amyloid-beta, tau pathology, neurodegeneration, intranasal insulinAbstract
Type 3 diabetes (T3D) is a proposed term for Alzheimer’s Disease (AD) that represents a form of diabetes that selectively involves the brain. This condition is characterized by brain-specific insulin resistance and insulin deficiency, which triggers a cascade of neurodegenerative processes. This review explores the pathophysiology, clinical presentation, and emerging therapeutic landscape for T3D.
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Would you like me to expand on the specific molecular signaling pathways (such as the PI3K/Akt pathway) involved in T3D?
