DYNAMICS OF THE ORAL MICROBIOME AND LOCAL IMMUNOLOGICAL STATUS IN EDENTULOUS PATIENTS FOLLOWING COMPLETE DENTURE PROSTHODONTICS
Keywords:
The primary objective of this clinical investigation is to perform a comparative analysis of the oral microbiota and local immune markers in edentulous patients, evaluating their status both prior to prosthetic intervention and at a six-month follow-up after the successful implantation of complete removable dentures.Abstract
The oral ecosystem is a complex environment where the presence of natural dentition, whether complete or partial, acts as a cornerstone for ecological stability [1]. Specific anatomical sites, such as dental fissures, carious lesions, endodontic canals, gingival sulci, and organized dental plaque, serve as specialized habitats that facilitate microbial proliferation and metabolic activity. The total or partial loss of teeth, followed by the subsequent introduction of removable dental prostheses, induces a profound reorganization of these environmental circumstances. Such transitions lead to significant modifications in the oral microbiota's composition and the physiological conditions of the mucosal surfaces [2].
References
1. Stafeev, A.A. Kolichestvennyi i kachestvennyi analiz mikrobioty polosti rta pri ortopedicheskoi reabilitatsii patsientov polnymi i chastichnymi s"emnymi plastinochnymi protezami / A.A. Stafeev, M.G. Chesnokova, V.A. Chesnokov // Ctomatologiya. – 2015. – №5. – S. 48 – 51. DOI: 10.17116/stomat201594548-51
2. Rol' narushenii proteoliticheskoi sistemy v patogeneze proteznogo stomatita / O.M. Lavrovskaya, Ya.A. Lavrovskaya, S.K. Severinova [i dr.] // Tavricheskii mediko biologicheskii vestnik. – 2019. – №1. – S. 164-169.
3. Pisarevskii, Yu.L. Stomatologicheskii sindrom u patsientov s akrilovymi s"emnymi zubnymi protezami na fone nedostatochnosti nizhnego pishchevodnogo sfinktera / Yu.L. Pisarevskii, I.V. Kibalina, A.I. Zhilina [i dr.] // Zabaikal'skii meditsinskii zhurnal. – 2024. – №3. – S. 9-14.
4. Fousert, E. Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses / E. Fousert, R. Toes, J. Desai // Cells. – 2020. – №9. – 915 p. DOI: https://doi.org/10.3390/cells9040915.
