SO'LAKNING PROTEOM PROFILI ASOSIDA YURAK-QON TOMIR ASORATLARINI BASHORAT QILISHDA UMUMIY PERIODONTITNI DAVOLASHGA SHAXSIYLASHTIRILGAN YONDASHUV
Keywords:
Tadqiqotda 140 nafar ishtirokchi qatnashdi (asosiy guruhni shaxsiylashtirilgan davolash olgan SUP va yurak-qon tomir xavfi bo'lgan 65 nafar bemor tashkil etdi; taqqoslash guruhini an'anaviy davolash olgan 45 nafar SUP bo'lgan bemor tashkil etdi; nazorat guruhini esa 30 nafar sog'lom kishi tashkil etdi). Keng qamrovli biokimyoviy, kardiologik va stomatologik ko'rik o'tkazildi. So'lakning proteom profili (apolipoproteinlar A1, B, E va sitokinlar) ELISA va LC-MS/MS mass-spektrometriya yordamida baholandi. R va Python muhitlarida statistik tahlil qilish uchun LASSO regressiyasi va ROC tahlili qo'llanildi.Abstract
Yurak-qon tomir kasalliklarining (YQTK) ma'lum bo'lgan modifikatsiyalanuvchi xavf omillaridan biri surunkali umumiy periodontitdir (SUP). Shaxsiylashtirilgan tibbiyotning qiziqarli yo'nalishlaridan biri hamroh patologiyalarni noinvaziv monitoring qilish uchun og'iz bo'shlig'i suyuqligi biomarkerlaridan foydalanish hisoblanadi.
Tadqiqot maqsadi. Hamroh patologiyasi bo'lgan bemorlarda og'iz bo'shlig'i suyuqligining proteom profili asosida yurak-qon tomir asoratlarini erta bashorat qilish algoritmini hamda SUP uchun shaxsiylashtirilgan davolash usulini yaratish va ilmiy jihatdan asoslash.
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