ANTIBIOTIC RESISTANCE: IDENTIFICATION AND ANALYSIS OF EMERGING BACTERIAL PHENOTYPES
Keywords:
Antibiotic resistance; bacterial phenotypes; antimicrobial resistance; genomic analysis; horizontal gene transfer; efflux pumps; resistance mechanisms; surveillance; diagnostics; public health.Abstract
Antibiotic resistance poses a significant threat to global public health, driven by the emergence of novel bacterial phenotypes capable of evading conventional therapies. This article explores methods for identifying and analyzing antibiotic-resistant bacteria, including genomic sequencing, phenotypic assays, and bioinformatics approaches. The study reviews mechanisms of resistance such as horizontal gene transfer, efflux pumps, and enzymatic inactivation. By examining recent outbreaks and resistant strains, the research emphasizes the importance of rapid detection, continuous surveillance, and development of innovative therapeutic strategies to combat antimicrobial resistance.¹
References
1. Ventola, C.L. The antibiotic resistance crisis: Part 1: Causes and threats. Pharmacy and Therapeutics, 2015.
2. WHO. Global action plan on antimicrobial resistance. World Health Organization, 2015.
3. Laxminarayan, R., Duse, A., Wattal, C., et al. Antibiotic resistance—the need for global solutions. The Lancet Infectious Diseases, 2013.
4. Blair, J.M.A., Webber, M.A., Baylay, A.J., et al. Molecular mechanisms of antibiotic resistance. Nature Reviews Microbiology, 2015.
5. Jorgensen, J.H., Ferraro, M.J. Antimicrobial susceptibility testing: General principles and contemporary practices. Clinical Infectious Diseases, 2009.
6. Lakin, S.M., Dean, C., Noyes, N.R., et al. MEGARes: An antimicrobial resistance database for high throughput sequencing. Nucleic Acids Research, 2017.
7. Alcock, B.P., Raphenya, A.R., Lau, T.T.Y., et al. CARD 2020: Antibiotic resistome surveillance with the comprehensive antibiotic resistance database. Nucleic Acids Research,
8. Ventola, C.L. The antibiotic resistance crisis: Part 2: Management strategies and new agents. Pharmacy and Therapeutics, 2015.