PATHOPHYSIOLOGICAL MECHANISMS AND CLINICAL SIGNIFICANCE OF HYPOTHYROIDISM
Keywords:
Keywords: Hypothyroidism, thyroid gland, thyroxine, myxedema, hypometabolism, basal metabolic rate (BMR), glycosaminoglycans, TSH (thyroid- stimulating hormone), cardiohemodynamics, levothyroxine.Abstract
Abstract: Hypothyroidism is a common endocrine disorder characterized by a
deficiency of thyroid hormones. According to current data, overt hypothyroidism
occurs in approximately 0.3–5% of the general population, while subclinical
hypothyroidism is found in about 4–10%, reaching up to 12% in some populations. It
is observed more frequently among women and elderly individuals.This condition
affects the body by disrupting metabolism, cardiovascular function, nervous system
activity, digestive processes, and reproductive function. Hypothyroidism often
develops slowly and insidiously, which may delay its early diagnosis. If not identified
and treated in time, it can lead to serious complications such as myxedema, infertility,
atherosclerosis, heart failure, and cognitive impairment. Therefore, studying the
pathophysiological mechanisms and clinical significance of hypothyroidism is of great
importance in modern medicine.
References
REFERENCES
1. Abdurashitovich, Z. F. (2024). APPLICATION OF MYOCARDIAL
CYTOPROTECTORS IN ISCHEMIC HEART DISEASES. Образование
наука и инновационные идеи в мире, 39(5), 152–159.
2. Narzulaeva, U. (2024). HEMORRHAGIC DISORDERS IN THE EARLY
STAGES OF ARTERIAL HYPERTENSION. Центральноазиатский журнал
междисциплинарных исследований и исследований в области управления,
1(2), 13–18.
3. Abdurashitovich, Z. F. (2024). ASTRAGAL O‘SIMLIGINING
TIBBIYOTDAGI MUHIM AHAMIYATLARI VA SOG‘LOM TURMUSH
TARZIGA TA’SIRI. Лучшие интеллектуальные исследования, 14(4), 111–
119.
4. Xafizova, M. H. (2024). Применения Числительных В Медицинской
Терминологии. Tadqiqotlar. Uz, 34(3), 116–122.
5. Irgashev, I. E. (2024). ПРИНЦИПЫ ПРИОРИТЕТА И ЕГО ЗНАЧЕНИЕ
ОКАЗАНИЯ ПЕРВОЙ ПОМОЩИ У БОЛЬНЫХ ОСТРЫМ
КОРОНАРНЫМ СИНДРОМОМ. TADQIQOTLAR. UZ, 34(2), 177–184.
6. Qilichovna, A. M. (2024). FACTORS CAUSING THE WIDE SPREAD OF
DENTAL CARIES. EUROPEAN JOURNAL OF MODERN MEDICINE AND
PRACTICE, 4(4), 154–160.
7. Abdurashitovich, Z. F. (2024). THE COMPLEXITY OF THE FUSION OF THE
BONES OF THE FOOT. JOURNAL OF HEALTHCARE AND LIFE-
SCIENCE RESEARCH, 3(5), 223–230.
8. Saloxiddinovna, X. Y. (2024). MORPHOFUNCTIONAL FEATURES OF THE
STRUCTURE AND DEVELOPMENT OF THE OVARIES. EUROPEAN
JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 220–227.
9. Abdurashitovich, Z. F. (2024). MORPHO-FUNCTIONAL ASPECTS OF THE
DEEP VEINS OF THE HUMAN BRAIN. Образование наука и
инновационные идеи в мире, 36(6), 203–206.
10. Tokhirovna, E. G. (2024). MECHANISM OF ACTION OF METFORMIN
(BIGUANIDE) IN TYPE 2 DIABETES. JOURNAL OF HEALTHCARE AND
LIFE-SCIENCE RESEARCH, 3(5), 210–216. 11. Abdurashitovich, Z. F. (2024). THE RELATIONSHIP OF STRESS FACTORS
AND THYMUS. Образование наука и инновационные идеи в мире, 36(6),
188–196.
12. Abdurashitovich, Z. F. (2024). MIOKARD INFARKTI UCHUN XAVF
OMILLARINING AHAMIYATINI ANIQLASH. Образование наука и
инновационные идеи в мире, 36(5), 83–89.
13. Tokhirovna, E. G. (2024). THE ROLE OF METFORMIN (GLIFORMIN) IN
THE TREATMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS.
EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4),
171–177.
14. Rakhmatova, D. B., & Zikrillaev, F. A. (2022). DETERMINE THE VALUE OF
RISK FACTORS FOR MYOCARDIAL INFARCTION. FAN, TA’LIM,
MADANIYAT VA INNOVATSIYA JURNALI / JOURNAL OF SCIENCE,
EDUCATION, CULTURE AND INNOVATION, 1(4), 23–28.
15. Abdurashitovich, Z. F. (2024). Department of Syndesmology from the Science
of Human Anatomy General Information About. Research Journal of Trauma
and Disability Studies, 3(3), 158–165.
16. Abdurashitovich, Z. F. (2024). THE IMPORTANCE OF THE ASTRAGAL
PLANT IN MEDICINE AND ITS EFFECT ON A HEALTHY LIFESTYLE.
Образование наука и инновационные идеи в мире, 41(4), 88–95.
17. Abdurashitovich, Z. F. (2024). ODAM ANATOMIYASI FANIDAN
SINDESMOLOGIYA BO‘LIMI HAQIDA UMUMIY MA’LUMOTLAR.
Образование наука и инновационные идеи в мире, 41(4), 37–45.
18. Abdurashitovich, Z. F. (2024). ANATOMICAL COMPLEXITIES OF JOINT
BONES OF THE HAND. EUROPEAN JOURNAL OF MODERN MEDICINE
AND PRACTICE, 4(4), 198–206.
19. Эргашева, Г. Т. (2024). Эффект Применения Бигуанида При Сахарным
Диабетом 2 Типа И Covid-19. Research Journal of Trauma and Disability
Studies, 3(3), 55–61.
20. Tog‘aydullayeva, D. D. (2024). MORPHOLOGICAL ASPECTS OF ANEMIA
IN SOMATIC DISEASES. EUROPEAN JOURNAL OF MODERN
MEDICINE AND PRACTICE, 4(4), 212–219.
21. Qilichovna, A. M., & Nematilloyevna, X. M. (2024). TIBBIYOT TILI
HISOBLANMISH LOTIN TILINI SAMARALI O‘RGANISH OMILLARI:
Yangi O‘zbekiston taraqqiyotida tadqiqotlarni o‘rni va rivojlanish omillari.
Yangi O‘zbekiston taraqqiyotida tadqiqotlarni o‘rni va rivojlanish omillari, 6(4),
197–206.
22. Toxirovna, E. G. (2024). GIPERPROLAKTINEMIYA KLINIK BELGILARI
VA BEPUSHTLIKKA SABAB BO‘LUVCHI OMILLAR. Лучшие
интеллектуальные исследования, 14(4), 168–175.
23. Olimjonovna, K. O. (2024). HYPOTHYROIDISM IN MENOPAUSAL
WOMEN RECOMMENDATIONS DEVELOPED ON THE BASIS OF
EXPERIENCE. EUROPEAN JOURNAL OF MODERN MEDICINE AND
PRACTICE, 4(4), 228–235.
24. Toxirovna, E. G. (2024). QANDLI DIABET 2-TUR VA O‘LIMNI KELTIRIB
CHIQARUVCHI SABABLAR. Лучшие интеллектуальные исследования,
14(4), 86–93.
25. Toxirovna, E. G. (2024). QANDLI DIABET 2 TUR VA YURAK QON TOMIR
KASALLIKLARINING BEMORLARDA BIRGALIKDA
26. (davomi keyingi sahifada bo‘lishi mumkin — rasmda oxiri ko‘rinmay qolgan)
