INFLAMMATORY COMPONENT OF EARLY KNEE OSTEOARTHRITIS IN PATIENTS WITH METABOLIC SYDROME
Abstract
Currently, approximately 15% of individuals aged 30 years and older are affected by osteoarthritis. A study published in The Lancet Rheumatology analyzed data spanning 30 years (1990–2020) from more than 200 countries. This study was conducted by the Institute for Health Metrics and Evaluation (IHME) as part of the Global Burden of Disease 2021 project.
The findings demonstrated a substantial increase in the number of osteoarthritis cases over the past three decades, driven by three main factors: population aging, population growth, and obesity. In 1990, osteoarthritis was diagnosed in 256 million people worldwide. By 2020, this number had risen to 595 million cases, representing a 132% increase compared to 1990. It is projected that by 2050, the global number of cases will reach 1 billion. According to Dr. Jaimie Steinmetz, a lead researcher at IHME and co-author of the study, “Given the key contributing factors, particularly increased life expectancy and global population growth, a growing burden on healthcare systems worldwide is expected.” Currently, there is no curative treatment for osteoarthritis; therefore, it is crucial to focus on prevention strategies, early diagnosis, and improving access—especially in low- and middle-income countries—to effective but costly interventions such as joint replacement.
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