SURUNKALI STRESS SHAROITIDA JIGAR QON TOMIRLARINING REGULYATOR-MORFOFUNKTSIONAL TRANSFORMATSIYASI
Keywords:
Kalit so‘zlar: neyroendokrin regulyatsiya, portal perfuziya, vazoregulyator disbalans, oksidativ modifikatsiya, endotelial homeostaz.Abstract
Annotatsiya: Surunkali psixoemotsional zo‘riqish organizmning neyroendokrin integrativ tizimlarini qayta konfiguratsiyalash orqali visseral organlar gemodinamikasiga ko‘p bosqichli ta’sir ko‘rsatadi. Mazkur tadqiqotda stress-induksiyalangan neyrohumoral mediatorlar fonida jigar qon tomirlari tonusi, mikrotsirkulyator arxitektonikasi va endotelial homeostaz ko‘rsatkichlari kompleks baholandi. Olingan ma’lumotlar stressning jigar portal tizimida vazoregulyator disbalans, perfuzion yetishmovchilik va oksidativ shikastlanish mexanizmlari orqali patomorfologik o‘zgarishlarni induksiya qilishini ko‘rsatdi.
References
1. Hans Selye. The Stress of Life. New York: McGraw-Hill; 1976.
2. Robert Sapolsky. Why Zebras Don't Get Ulcers. 3rd ed. New York: Holt Paperbacks; 2017.
3. Bruce McEwen. Protective and damaging effects of stress mediators. New England Journal of Medicine. 1998;338(3):171–179.
4. Stephen A. Friedman. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008;134(6):1655–1669.
5. Cary P. West, Liselotte N. Dyrbye, Tait D. Shanafelt. Physician burnout: contributors, consequences and solutions. Journal of Internal Medicine. 2018;283(6):516–529.
6. Guyton and Hall Textbook of Medical Physiology. Philadelphia: Elsevier; 2021.
7. Virdis A., Giannarelli C., Neves M.F., Taddei S., Ghiadoni L. Cigarette smoking and hypertension: role of oxidative stress. Current Pharmaceutical Design. 2010;16(23):2518–2525.
8. Grassi G., Seravalle G., Quarti-Trevano F. The ‘neuroadrenergic hypothesis’ in hypertension. Current Hypertension Reports. 2010;12(5):285–289.
9. Tanaka M., Okamura T. Stress and hepatic circulation: pathophysiological mechanisms. World Journal of Hepatology. 2020;12(4):123–135.
10. Kim Y.S., Lee Y.J. Endothelial dysfunction in stress-related disorders. International Journal of Molecular Sciences. 2021;22(4):1895.
11. Iwakiri Y., Groszmann R.J. The hyperdynamic circulation of chronic liver diseases. Hepatology. 2006;43(S1):S121–S131.
12. Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biology. 2015;4:180–183.