KO‘KRAK BEZI SARATONINI ERTA ANIQLASHDA MAMMOGRAFIYA VA ULTRATOVUSH TEKSHIRUVINING AHAMIYATI
Keywords:
Kalit so‘zlar: ko‘krak bezi saratoni, mammografiya, ultratovush tekshiruvi (UTT), skrining, BI-RADS, onkologiya, rentgenologiya, profilaktika.Abstract
Annotatsiya: Ko‘krak bezi saratoni (KBS) global miqyosda ayollar salomatligiga tahdid soluvchi eng keng tarqalgan onkologik kasallik bo‘lib, o‘lim ko‘rsatkichlarini kamaytirishning yagona samarali yo‘li bu — erta diagnostikadir. Mazkur maqolada erta tashxis qo‘yishda mammografiya va ultratovush tekshiruvining (UTT) o‘rni zamonaviy klinik tadqiqotlar va xalqaro tavsiyalar asosida tahlil qilinadi. Raqamli mammografiya skriningning "oltin standarti" hisoblansa-da, uning samaradorligi ko‘krak to‘qimasining zichligiga bevosita bog‘liq. Tadqiqotlar shuni ko‘rsatadiki, o‘ta zich ko‘krak to‘qimalariga (BI-RADS D toifasi) ega ayollarda mammografiya sezgirligi pasayadi va bu guruhda saraton rivojlanish xavfi ikki baravar yuqori bo‘ladi. Ushbu muammoni hal qilishda UTT usulidan qo‘shimcha diagnostika vositasi sifatida foydalanish muhim ahamiyatga ega. Mammografiya va UTTning kombinatsiyalashgan holda qo‘llanilishi har 1000 nafar ayoldan qo‘shimcha 2–3 ta yashirin saraton holatini aniqlash imkonini beradi. Shuningdek, maqolada sun’iy intellekt (AI) texnologiyalarining tasvirlarni tahlil qilishdagi o‘rni hamda axillar limfa tugunlarini baholashda UTTning jarrohlik amaliyotlarini optimallashtirishdagi samaradorligi (SOUND tadqiqoti misolida) ko‘rib chiqiladi. Tadqiqot natijalari shuni ko‘rsatadiki, individual xavf omillariga asoslangan holda ushbu ikki usulni integratsiya qilish ko‘krak bezi saratonini erta aniqlashning eng ishonchli strategiyasidir.
References
1.Bodewes, F. T. H., van Asselt, A. A., Dorrius, M. D., Greuter, M. J. W., & de Bock, G. H. (2022). Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis. The Breast, 66, 113-122. doi.org (Mammografik ko‘krak zichligi va ko‘krak bezi saratoni xavfi: Tizimli sharh va meta-tahlil // Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis).
2.Duffy, S. W., Tabár, L., Yen, A. M., Dean, P. B., & Smith, R. A. (2020). Mammography screening reduces rates of advanced and fatal breast cancers: results in 549,091 women. Cancer, 126(13), 2971-2979. (Mammografiya skriningi rivojlangan va o'limga olib keladigan ko'krak bezi saratoni darajasini pasaytiradi // Mammography screening reduces rates of advanced and fatal breast cancers).
3.Eisemann, N., Bunk, S., Mukama, T., Baltus, H., & Katalinic, A. (2024). Nationwide real-world implementation of AI for cancer detection in population-based mammography screening. Nature Medicine. doi.org (Sun’iy intellektni mammografiya skriningida qo‘llashning umummilliy natijalari // Nationwide real-world implementation of AI for cancer detection in population-based mammography screening).
4.Gentilini, O. D., Botteri, E., Sangalli, C., & Galimberti, V. (2023). Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer: The SOUND Randomized Clinical Trial. JAMA Oncology, 9(11), 1557-1564. (Kichik ko‘krak bezi saratonida aksillar jarrohlikdan voz kechish: SOUND klinik sinovi // Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer: The SOUND Randomized Clinical Trial).
5.G'oziyev, E. G. (2010). Umumiy psixologiya. Toshkent: Sharq. (General Psychology // General Psychology).
6.Harmer, V. (2021). Breast cancer: Awareness and common benign diseases. British Journal of Nursing, 17(15), 950-955. (Ko'krak bezi saratoni: xabardorlik va keng tarqalgan xavfsiz kasalliklar // Breast cancer: Awareness and common benign diseases).
7.Hernström, V., Josefsson, V., Sartor, H., & Lång, K. (2025). Screening performance and characteristics of breast cancer detected in the MASAI trial. The Lancet Digital Health, 7(3), e175-e183. (MASAI sinovida aniqlangan saraton xususiyatlari va skrining samaradorligi // Screening performance and characteristics of breast cancer detected in the MASAI trial).
8.Katsura, C., Ogunmwonyi, I., Kankam, H. K., & Saha, S. (2022). Breast cancer: presentation, investigation and management. British Journal of Hospital Medicine, 83(2), 1-7. (Ko‘krak bezi saratoni: klinik ko‘rinishi va davolash // Breast cancer: presentation, investigation and management).
9.Lång, K., Josefsson, V., Larsson, A. M., & Rosso, A. (2023). Artificial intelligence-supported screen reading versus standard double reading in the MASAI trial. The Lancet Oncology, 24(8), 936-944. (Sun’iy intellekt yordamida skriningni o‘qish va standart usul tahlili // Artificial intelligence-supported screen reading versus standard double reading in the MASAI trial).
10.Lehman, C. D., Wellman, R. D., Buist, D. S., Kerlikowske, K., & Tosteson, A. N. (2021). Diagnostic Accuracy of Digital Screening Mammography with and without Computer-Aided Detection. JAMA Internal Medicine, 175(11), 1828-1837. (Kompyuter yordamida aniqlash bilan va usiz raqamli mammografiyaning aniqligi // Diagnostic Accuracy of Digital Screening Mammography with and without Computer-Aided Detection).
11.Mann, R. M., & Teuwen, J. (2024). Beyond the AJR: A Breakthrough in the Use of Artificial Intelligence for Mammography. AJR American Journal of Roentgenology, 222(6). (Mammografiya uchun sun'iy intellektdan foydalanishdagi yutuqlar // Breakthrough in the Use of Artificial Intelligence for Mammography).
12.Melnikow, J., Fenton, J. J., Whitlock, E. P., & Miglioretti, D. L. (2021). Supplemental Screening for Breast Cancer in Women With Dense Breasts. AHRQ Publication, 14-05201. (Zich ko'krakli ayollarda qo'shimcha ko'krak bezi saratoni skriningi // Supplemental Screening for Breast Cancer in Women With Dense Breasts).
13.Richman, I. B., Long, J. B., Soulos, P. R., & Gross, C. P. (2023). Estimating Breast Cancer Overdiagnosis After Screening Mammography. Annals of Internal Medicine, 176(9), 1172-1180. (Skrining mammografiyasidan keyin haddan tashqari diagnostikani baholash // Estimating Breast Cancer Overdiagnosis After Screening Mammography).
14.Sardanelli, F., & Scaperrotta, G. (2025). Artificial intelligence for breast cancer prevention: the vision ahead. European Radiology, 36(2), 800-807. (Ko'krak bezi saratonining oldini olishda sun'iy intellekt: kelajakdagi qarashlar // Artificial intelligence for breast cancer prevention: the vision ahead).
15.U.S. Preventive Services Task Force. (2024). Screening for Breast Cancer: Recommendation Statement. JAMA, 331(22), 1918-1930. (Ko‘krak bezi saratoni skriningi bo‘yicha tavsiyalar // Screening for Breast Cancer: Recommendation Statement).
16.Zackrisson, S., Lång, K., Rosso, A., & Andersson, I. (2018). One-view breast tomosynthesis versus two-view mammography in the MBTST trial. The Lancet Oncology, 19(11), 1493-1503. (MBTST sinovida bir ko'rinishli tomosintez va ikki ko'rinishli mammografiya tahlili // One-view breast tomosynthesis versus two-view mammography).
