TERI VA ICHKI QARISHGA TAʼSIR ETUVCHI OMILLAR: BIOLOGIK, ATROF-MUHIT VA TERAPEVTIK JIHATLAR
Keywords:
Kalit soʻzlar: Biologik mexanizmlar | atrof-muhit omillari | tashqi (ekstrinsik) qarish | ichki (intrinsik) qarish | teri qarishi.Abstract
Annotatsiya: Qarish jismoniy funksiyalarning bosqichma-bosqich yomonlashuvi va kasalliklarga moyillikning ortishi bilan tavsiflanib, barcha organ va toʻqimalarga, ayniqsa teriga taʼsir koʻrsatadi. Teri qarishi ichki omillar (genetika, hujayra metabolizmi) va tashqi omillar (atrof-muhit, turmush tarzi) taʼsirida yuzaga keladi. Bu mexanizmlarni tushunish sogʻlom qarishni ragʻbatlantirish va teri qarishi taʼsirini kamaytirish uchun juda muhimdir. Ushbu sharh teri va ichki qarishga taʼsir etuvchi asosiy omillarni umumlashtirib, ularning tagida yotuvchi mexanizmlar va hissa qoʻshuvchi elementlar haqida keng tushuncha berishga qaratilgan.References
1. Sanchez NP, Pathak MA, Sato S, Fitzpatrick TB, Sanchez JL, Mihm MC Jr. Melazma: klinik, yorug‘lik mikroskopik, ultrastruktural va immunofluoresensiya tadqiqoti. J Am Acad Dermatol. 1981;4(6):698–710. doi:10.1016/S0190- 9622(81)70125-0. PMID: 6787100.
2. Guinot C, Cheffai S, Latreille J, Dhaoui MA, Youssef S, Jaber K, va boshqalar. Melazmani kuchaytiruvchi omillar: 197 nafar tunislik bemorda o‘tkazilgan T A D Q I Q O T L A R jahon ilmiy – metodik jurnali https://journalss.org 211 81-son_1-to’plam_Mart-2026 ISSN:3030-3613 perspektiv tadqiqot. J Eur Acad Dermatol Venereol. 2010;24(9):1060–1069. doi:10.1111/j.1468-3083.2010.03606.x. PMID: 20202051.
3. Tamega Ade A, Miot LD, Bonfietti C, Gige TC, Marques ME, Miot HA. Clinical patterns and epi demiological characteristics of facial melasma in Brazilian women. J Eur Acad Dermatol Venereol. 2013;27(2):151–6 (PubMed PMID: 22212073).
4. Mandry Pagan R, Sanchez JL. Mandibular melasma. P R Health Sci J. 2000;19(3):231–4 (PubMed PMID: 11076368).
5. Ritter CG, Fiss DV, Borges da Costa JA, de Carvalho RR, Bauermann G, Cestari TF. Extra-facial melasma: clinical, histopathological, and immunohisto chemical case–control study. J Eur Acad Dermatol Venereol. 2013;27(9):1088–94 (PubMed PMID: 22827850).
6. Hexsel D, Lacerda DA, Cavalcante AS, Machado Filho CA, Kalil CL, Ayres EL
7. Mishra SN, Dhurat RS, Deshpande DJ, Nayak CS. Diagnostic utility of dermatoscopy in hydro quinone-induced exogenous ochronosis. Int J Der matol. 2013;52(4):413–7 22348652). (PubMed PMID:
8. Achar A, Rathi SK. Melasma: a clinico-epidemio logical study of 312 cases. Indian J Dermatol. 2011;56(4):380–2 (PubMed PMID: 21965843. Pubmed Central PMCID: 3178998).
9. Grimes PE, Yamada N, Bhawan J. Light microscopic, immunohistochemical, and ultrastructural alter ations in patients with melasma. Am J Der matopathol. 2005;27(2):96–101 (PubMed PMID: 15798432).
10. Kang HY, Bahadoran P, Suzuki I, Zugaj D, Khemis A, Passeron T, et al. In vivo reflectance confocal microscopy detects pigmentary changes in melasma at a cellular level resolution. Exp Dermatol. 2010;19(8):e228–33 (PubMed PMID: 20497220)
