PARKINSON’S DISEASE – PATHOGENESIS, CLINICAL FEATURES, AND DIAGNOSTIC STRATEGIES
Keywords:
Keywords: Parkinson’s disease, α-synuclein, Lewy bodies, substantia nigra, bradykinesia, tremor, neurodegeneration, biomarkers.Abstract
Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms that significantly impair quality of life. The disease results primarily from degeneration of dopaminergic neurons in the substantia nigra pars compacta and the presence of intracellular α-synuclein aggregates known as Lewy bodies. This article reviews current understanding of the molecular mechanisms, clinical manifestations, and diagnostic approaches in Parkinson’s disease.
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