MORPHOLOGICAL ORGANIZATION OF THE HEART AND FEATURES OF HYPOXIC CHANGES IN THE MYOCARDIUM UNDER THE INFLUENCE OF CARBON MONOXIDE
Keywords:
carbon monoxide, morphology, hypoxia, cardiomyocytes.Abstract
The article presents modern data on morphological changes in the heart under
the influence of carbon monoxide. Carbon monoxide induces hypoxic damage to the
myocardium, accompanied by disturbances in the structural organization of
cardiomyocytes and microcirculation. Mitochondrial destruction, sarcoplasmic
swelling, myofibril fragmentation, and stromal edema are observed. The degree of
morphological disorders correlates with the duration and concentration of carbon
monoxide exposure. Experimental and clinical findings provide a basis for further
studies of the mechanisms of the toxic cardiomyopathic effect of carbon monoxide.
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