PATHOMORPHOLOGICAL CHANGES IN CARDIAC MUSCLE IN CHRONIC KIDNEY DISEASE
Keywords:
chronic kidney disease, myocardium, uremic cardiomyopathy, myocardial hypertrophy, fibrosisAbstract
Chronic kidney disease (CKD) is a progressive systemic disorder characterized
by irreversible impairment of renal excretory, metabolic, and endocrine functions,
leading to widespread structural and functional alterations in multiple organs. Among
these, the cardiovascular system—particularly the myocardium—represents the most
vulnerable target. Persistent uremic intoxication, arterial hypertension, anemia,
electrolyte imbalance, and disturbances in calcium–phosphorus metabolism
collectively contribute to profound myocardial remodeling. These pathological
processes result in cardiomyocyte hypertrophy, interstitial fibrosis, microvascular
damage, and progressive deterioration of myocardial contractility. The constellation of
these alterations forms the morphological basis of uremic cardiomyopathy. This article
analyzes the mechanisms, histopathological features, and clinical implications of
myocardial pathomorphological changes associated with chronic kidney disease based
on contemporary scientific literature.
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