INFLUENCE OF HIGH-DOSE ACUTE RADIATION ON MICROBIAL GROWTH PATTERNS: EXPERIMENTAL FINDINGS

Authors

  • Jabborova Oysha Iskandarovna Author

Keywords:

Microorganism, immune system, translocation, bacteriological examination, biocorrection, immunodeficiency.

Abstract

The main objective of this research work was to determine the 
percentage of germination of microorganisms translocated from the large intestine to 
the internal organs. The percentage of microorganisms that passed through the large 
intestine from the peripheral blood of irradiated laboratory animals increased as the 
observation period increased. Analysis of the results showed that irradiation increases 
the permeability of the colon mucosa against the background of general 
immunodeficiency. In prophylactically biocorrected, irradiated animals, the percentage 
of germination of microorganisms decreased over time. In both groups, its values were 
significantly higher than in the control group. The aim of the study was to 
experimentally study the degree of occurrence of microorganisms that provide the 
phenomenon of bacterial translocation in the dynamics of observation under the 
influence of acute irradiation. 

References

1. Ferrando M.L., Schultsz C. A hypothetical model of host-pathogen interaction of

Streptococcus suis in the gastro-intestinal tract // Gut Microbes. - 2016. - N 7(2). -

P.154-162.

2. Hofer U., Schlaepfer E., Baenziger S. Inadequate Clearance of Translocated

Bacterial Products in HIV-Infected Humanized Mice // PLoS Pathogens. - 2010. - N

6. - P.1-10.

3. Jabborova, O. I., & Iskandarov, U. E. (2021). Study of the immunology of

complications after kidney transplantation. Central Asian Journal of Medical and

Natural Science, 2(3), 99-101.

4. Iskandarovna, J. O., & Abdullaevich, N. N. (2022). Description of the characteristics

of the effect of acute radiation on the phenomenon of bacterial translocation. Journal

of biomedicine and practice, 7(5).

5. Nuraliev, N. A., & Zhabborova, O. I. (2022). Analysis of the Results of Studying

the Effect of Acute Irradiation on the Normal Microflora of the Large Intestine of

Laboratory Animals in Dynamics. Central Asian Journal of Medical and Natural

Science, 3(5), 396-403.

6. Nuraliev, N. A., & Zhabborova, O. I. (2022). Indicators of inoculation of

microorganisms translocated from the large intestine to internal organs under the

influence of acute irradiation in the experiment. In Current issues in experimental

microbiology: theory, methodology, practice, innovation (pp. 157-160).

Published

2025-12-20

How to Cite

INFLUENCE OF HIGH-DOSE ACUTE RADIATION ON MICROBIAL GROWTH PATTERNS: EXPERIMENTAL FINDINGS. (2025). ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 84(1), 40-45. https://journalss.org/index.php/obr/article/view/11644