INFLUENCE OF HIGH-DOSE ACUTE RADIATION ON MICROBIAL GROWTH PATTERNS: EXPERIMENTAL FINDINGS
Keywords:
Microorganism, immune system, translocation, bacteriological examination, biocorrection, immunodeficiency.Abstract
The main objective of this research work was to determine the
percentage of germination of microorganisms translocated from the large intestine to
the internal organs. The percentage of microorganisms that passed through the large
intestine from the peripheral blood of irradiated laboratory animals increased as the
observation period increased. Analysis of the results showed that irradiation increases
the permeability of the colon mucosa against the background of general
immunodeficiency. In prophylactically biocorrected, irradiated animals, the percentage
of germination of microorganisms decreased over time. In both groups, its values were
significantly higher than in the control group. The aim of the study was to
experimentally study the degree of occurrence of microorganisms that provide the
phenomenon of bacterial translocation in the dynamics of observation under the
influence of acute irradiation.
References
1. Ferrando M.L., Schultsz C. A hypothetical model of host-pathogen interaction of
Streptococcus suis in the gastro-intestinal tract // Gut Microbes. - 2016. - N 7(2). -
P.154-162.
2. Hofer U., Schlaepfer E., Baenziger S. Inadequate Clearance of Translocated
Bacterial Products in HIV-Infected Humanized Mice // PLoS Pathogens. - 2010. - N
6. - P.1-10.
3. Jabborova, O. I., & Iskandarov, U. E. (2021). Study of the immunology of
complications after kidney transplantation. Central Asian Journal of Medical and
Natural Science, 2(3), 99-101.
4. Iskandarovna, J. O., & Abdullaevich, N. N. (2022). Description of the characteristics
of the effect of acute radiation on the phenomenon of bacterial translocation. Journal
of biomedicine and practice, 7(5).
5. Nuraliev, N. A., & Zhabborova, O. I. (2022). Analysis of the Results of Studying
the Effect of Acute Irradiation on the Normal Microflora of the Large Intestine of
Laboratory Animals in Dynamics. Central Asian Journal of Medical and Natural
Science, 3(5), 396-403.
6. Nuraliev, N. A., & Zhabborova, O. I. (2022). Indicators of inoculation of
microorganisms translocated from the large intestine to internal organs under the
influence of acute irradiation in the experiment. In Current issues in experimental
microbiology: theory, methodology, practice, innovation (pp. 157-160).