CLINICAL INTERPRETATION AND LABORATORY ADVANCES IN TROPONIN MEASUREMENT
Keywords:
troponin, acute myocardial infarction, biomarker, analytical sensitivity, clinical sensitivity, assay accuracy, cardiovascular diagnostics, laboratory testing.Abstract
Troponin is the key biomarker for diagnosing acute myocardial
infarction and plays a pivotal role in clinical cardiology. Advances in laboratory
assays over the past decades have significantly improved analytical sensitivity and
accuracy, enabling detection of very low troponin concentrations. Effective clinical
use requires understanding both the analytical and clinical sensitivity and specificity
of assays, as well as proper interpretation within the patient’s clinical context.
Variability among troponin I and T tests and evolving definitions of sensitivity pose
challenges for clinicians, emphasizing the need to integrate laboratory results with
clinical reasoning. Enhanced understanding of troponin testing is crucial for accurate
diagnosis, timely intervention, and improved cardiovascular outcomes.
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