MODERN APPROACHES TO THE DIAGNOSIS AND MANAGEMENT OF NEONATAL HYPERBILIRUBINEMIA
Keywords:
Neonatal hyperbilirubinemia; neonatal jaundice; bilirubin metabolism; phototherapy; transcutaneous bilirubin; kernicterus; neonatal screening.Abstract
Neonatal hyperbilirubinemia is one of the most common clinical
conditions observed in the early neonatal period and remains a significant cause of
preventable neurological morbidity worldwide. Although the majority of newborns
develop physiological jaundice, a considerable proportion are at risk of progressing to
severe hyperbilirubinemia with potential complications such as acute bilirubin
encephalopathy and kernicterus. Advances in understanding bilirubin metabolism,
neurotoxicity mechanisms, and risk factors have led to the development of modern
diagnostic and management strategies
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