CLINICAL AND LABORATORY ASPECTS OF VITAMIN B12 DEFICIENCY: THE IMPORTANCE OF FUNCTIONAL BIOMARKERS
Keywords:
B12- deficiency anemia, internal Castle factor, macrocytic anemia, methylmalonic acid, homocysteine.Abstract
Vitamin B12 deficiency is a common clinical problem, particularly
among elderly patients, women of reproductive age, children, and adolescents.
Subclinical forms often remain asymptomatic, which may delay diagnosis and lead to
irreversible neurological complications. Therefore, early detection of vitamin B12
deficiency and implementation of preventive measures is of significant clinical
importance.
References
1. Whittingham S, Mackay IR. Autoimmune gastritis: historical antecedents,
outstanding discoveries, and unresolved problems. Int Rev Immunol. 2005; 24:1-2.
2. Schilling RF. Intrinsic factor studies II. The effect of gastric juice on the urinary
excretion of radioactivity after the oral administration of radioactive vitamin B12. J
Lab Clin Med. 1953;42:860-866.
3. Nobel Prize.org. Updated 16 June 2005. The Nobel Foundation. Available at:
http://www.nobelprize.org. Accessed 11 Aug 2005
4. Красновский А. Л. и др. Современные возможности диагностики и лечения
дефицита витамина В12 //Клиницист. – 2016. – Т. 10. – №. 3. – С. 15-25.
5. Левина А. А. и др. Дифференциальная диагностика анемий //Клиническая
лабораторная диагностика. – 2015. – Т. 60. – №. 12. – С. 26-30.
6. Силивончик Н. Н. ВИТАМИН В12 //Приложение к журналу «Лечебное дело». – 2021. – С. 13.
7. Крупенина Е. И. Клиническая лабораторная диагностика и картина крови при
В12-дефицитной анемии //Мечниковские чтения-2020. – 2020. – с. 210-211.
