The ROLE OF INFLAMMATORY MARKERS IN AUTOIMMUNE RHEUMATIC DISEASES

Authors

  • Razzakov Nabijon Alijonovich Author
  • Mirzarahmonova Robiya Nozimjon qizi Author

Keywords:

autoimmune diseases, rheumatic diseases, inflammatory markers, cytokines, C-reactive protein, erythrocyte sedimentation rate, diagnosis, disease activity, biomarkers, immunopathogenesis.

Abstract

Autoimmune rheumatic diseases represent a diverse and complex 
group of disorders in which the immune system mistakenly targets the body's own 
tissues, resulting in chronic inflammation and tissue damage across multiple organ 
systems. These diseases, such as rheumatoid arthritis, systemic lupus erythematosus, 
and Sjögren's syndrome, are characterized by their heterogeneous clinical 
manifestations, unpredictable course, and potential for significant morbidity. In the 
management of these disorders, early and accurate assessment of disease activity as 
well as timely monitoring of treatment response are critical. Among various tools used 
in clinical practice, inflammatory markers play a central role in both the diagnosis and 
ongoing evaluation of autoimmune rheumatic diseases. 

References

1. Aletaha, D., & Smolen, J. S. (2018). Diagnosis and management of rheumatoid

arthritis: A review. JAMA, 320(13), 1360-1372.

2. Boulos, P. T., Davis, S. A., & Feldman, S. R. (2020). Biomarkers in

autoimmune diseases: Current and future directions. Current Allergy and Asthma

Reports, 20(10), 52.

3. Deane, K. D., & Holers, V. M. (2019). The natural history of rheumatoid

arthritis. Clinics in Geriatric Medicine, 35(3), 407-418.

4. Firestein, G. S., & McInnes, I. B. (2017). Immunopathogenesis of rheumatoid

arthritis. Immunity, 46(2), 183-196.

5. Li, J., & Chen, Y. (2022). Inflammatory biomarkers in autoimmune diseases:

Pathogenesis and clinical application. Frontiers in Immunology, 13, 840885.

6. Marzaioli, V., Piccio, L., & Deana, C. (2019). Inflammation and biomarkers in

systemic lupus erythematosus. Journal of Clinical Medicine, 8(8), 1201.

7. Pepys, M. B., & Hirschfield, G. M. (2019). C-reactive protein: A critical update.

Journal of Clinical Investigation, 129(12), 5351-5357.

Published

2026-02-08

How to Cite

The ROLE OF INFLAMMATORY MARKERS IN AUTOIMMUNE RHEUMATIC DISEASES. (2026). ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 87(1), 78-82. https://journalss.org/index.php/obr/article/view/18145