TREPONEMA TURKUMIDAGI BAKTERIYALARNING QIYOSIY TAHLILI: INSON VA HAYVON TREPONEMALARINING PATOGENLIK XUSUSIYATLARI
Keywords:
Treponema pallidum, Treponema paraluiscuniculi, Zaxm (sifilis), Quyon sifilisi, Genetik izolyatsiya, Vaktsinatsiya, Patogenlik, Immun reaksiya.Abstract
Ushbu maqolada Treponema turkumiga mansub bakteriyalarning ikki turi —
inson patogeni Treponema pallidum va hayvon (quyon) patogeni Treponema
paraluiscuniculi o‘rtasidagi genetik va biologik tafovutlar qiyosiy tahlil qilinadi.
Tadqiqotda ushbu mikroorganizmlarning xojayin hujayralariga moslashish
mexanizmlari, ularning o‘zaro "aralashishi" natijasida yuzaga kelishi mumkin bo‘lgan
mutatsion o‘zgarishlar va inson immun tizimining hayvon treponemalariga reaksiyasi
o‘rganilgan. Natijalar shuni ko‘rsatadiki, turlararo to‘siqlar tufayli hayvon sifilisi inson
uchun patogen emas, biroq u sifilisga qarshi vaktsina yaratishda muhim immunogen
manba bo‘lib xizmat qilishi mumkin.
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