ODAM GENOMINING TIBBIYOTDAGI AMALIY AHAMIYATI
Keywords:
genom, DNK, gen terapiyasi, CRISPR, personalizatsiyalashgan tibbiyot, mutatsiya, genetik kasalliklar.Abstract
Ushbu maqolada odam genomining tuzilishi, uni o‘rganish
jarayonida erishilgan yutuqlar hamda genomik ma’lumotlarning tibbiyotdagi amaliy
ahamiyati yoritilgan. Genom tahlili yordamida irsiy kasalliklarni aniqlash, dori
vositalarining individual ta’sirini baholash, shuningdek, shaxsiy tibbiyot
(personalizatsiyalashgan tibbiyot) konsepsiyasining rivojlanishi ko‘rib chiqiladi.
Zamonaviy genom tahriri texnologiyalari, xususan CRISPR/Cas9 tizimi, gen terapiyasi
va profilaktik diagnostika yo‘nalishlaridagi innovatsion yondashuvlar tahlil qilinadi.
References
1. Collins F.S., Venter J.C. The Human Genome Project: progress and prospects.
Science, 2001.
2. National Human Genome Research Institute. A complete human genome sequence.
Nature, 2022.
3. Lander E.S. Initial sequencing and analysis of the human genome. Nature, 2001.
4. Doudna J., Charpentier E. The new frontier of genome editing with CRISPR/Cas9.
Science, 2014.
5. Visscher P.M. et al. 10 years of GWAS discovery: biology, function, and translation.
Am J Hum Genet, 2017.
