ANALYSIS OF CORRELATIONS BETWEEN CLINICAL, MORPHOLOGICAL, AND MOLECULAR FACTORS IN REGIONAL COLORECTAL CANCER METASTASIS
Keywords:
This retrospective study analyzed data from 103 patients treated at the Russian Scientific and Practical Center of Oncology and Radiology between 2016 and 2022. Tumor tissue samples were collected and subjected to immunohistochemical analysis to assess EGFR and VEGF expression,Abstract
To evaluate the relationships between clinical, morphological, and molecular factors—
specifically the expression of EGFR and VEGF—and their association with regional
metastasis in colorectal cancer, aiming to improve prognostic accuracy and guide
personalized treatment strategies.
References
The study confirms that clinical and morphological factors, particularly lymph node
involvement and extracapsular invasion, are strongly correlated with disease
progression in colorectal cancer. Positive EGFR and VEGF expression are associated
with higher recurrence risk and may serve as valuable prognostic markers and
therapeutic targets. Integrating these molecular and clinical parameters could enhance
predictive accuracy and support the development of personalized treatment
approaches. Further research is warranted to validate these findings and optimize
strategic interventions.
