PARKINSON KASALLIGIDA QOʻLLANILADIGAN YANGI FARMAKOLOGIK TERAPIYALAR
Keywords:
Parkinson kasalligi, farmakologik terapiya, dopamin agonistlari, A2A antagonistlari, gen terapiya.Abstract
Mazkur maqolada Parkinson kasalligining patogenez
mexanizmlari, an’anaviy farmakologik davolash usullari va so‘nggi yillarda ishlab
chiqilgan yangi terapiya strategiyalari yoritilgan. Yangi farmakologik preparatlar
qatoriga adenozin A2A retseptor antagonistlari, gen terapiyasi asosidagi dori vositalari,
neyroprotektiv agentlar, immunomodulyator preparatlar va hujayra terapiyasi bilan
bog‘liq farmakologik yondashuvlar kiradi. Maqolada ushbu dori vositalarining
samaradorligi, klinik qo‘llanilishi, afzalliklari va kamchiliklari ilmiy manbalar asosida
tahlil qilinadi.
References
1. Kalia LV, Lang AE. "Parkinson’s disease." Lancet. 2015;386(9996):896–912.
2. Stocchi F, Rascol O. "New pharmacological approaches to Parkinson’s disease."
Lancet Neurol. 2019;18(6):559–572.
3. Olanow CW, Schapira AH. "Therapeutic prospects for Parkinson’s disease." Ann
Neurol. 2018;83(6):980–993.
4. Poewe W, Seppi K, Tanner CM, et al. "Parkinson disease." Nature Reviews Disease
Primers. 2017;3:17013.
5. Ferreira JJ, Lees A, Rocha JF, Poewe W. "Safinamide for the treatment of
Parkinson’s disease." Expert Rev Clin Pharmacol. 2018;11(6):513–524.
