ROLE OF PARATHORMONE IN THE DEVELOPMENT OF ATHEROSCLEROSIS IN THE CAROTID ARTERY
Keywords:
parathormon, bone metabolism, endothelial dysfunction, dyslipidemia, insulin resistance.Abstract
Atherosclerosis of the carotid artery is a major risk factor for stroke and
cardiovascular diseases. Parathormone (PTH), primarily known for its role in calcium
and phosphate metabolism, has been increasingly implicated in vascular
pathophysiology. This review explores the potential mechanisms by which PTH
contributes to carotid atherosclerosis, including endothelial dysfunction, vascular
calcification, oxidative stress, and inflammation. Understanding these pathways could
provide new insights into the prevention and management of atherosclerotic diseases.
This review examines the role of PTH in the pathogenesis of carotid atherosclerosis
and its potential implications for cardiovascular risk management. PTH has pleiotropic
effects on the cardiovascular system. Beyond its classical role in bone metabolism, it
exerts direct effects on vascular smooth muscle cells (VSMCs), endothelial cells, and
inflammatory pathways.
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