“EVALUATION OF IMMUNE PARAMETERS AND MODULATORY EFFECTS ON IMMUNE CELLS INDUCED BY NATURAL BIOACTIVE COMPOUNDS DERIVED FROM (CHLORELLA VULGARIS)”
Keywords:
The thymalin immunostimulator increased the number of antibody-producing cells (APC) to 5241 ± 637, representing a 5.0-fold increase. The natural biologically active medicinal compound from Chlorella vulgaris increased the number of APCs to 6150 ± 687, a 4.5-fold increase, and in a 1% solution, the number of antibody producing cells rose to 8052 ± 673, representing a 6.1-fold increase (p < 0.05).Abstract
Humans have long been exploring nature to discover new plant and
animal species and to utilize them for economic purposes. Although the development
of new plant varieties introduced the concept of "cultivated plants," an entire
industry—technical microbiology—emerged, harnessing the activity of bacteria and
microscopic fungi to isolate valuable compounds. Until relatively recently, the vast
world of microscopic algae, particularly unicellular algae, remained largely unexplored
within the scope of human practical activity. When microalgae finally became a focus
of study and their potential as unique producers of essential compounds was
recognized, Chlorella vulgaris emerged as the most suitable candidate for large-scale
cultivation.The identification of antibody-producing cells in the spleen was carried out
using the localized hemolysis method on agar, as described by Nordin and Jerne
(1963). Toxic hepatitis was used to model secondary immunodeficiency. Rats with
toxic hepatitis were administered a 20% solution of CCl₄ (0.2 ml) over three
consecutive days and subsequently immunized with erythrocytes, which were injected
intraperitoneally.
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