CHANGES IN ARTERIAL BLOOD PRESSURE IN PATIENTS WITH VIRAL HEPATITIS: CLINICAL AND PATHOPHYSIOLOGICAL PERSPECTIVES
Keywords:
Viral hepatitis; arterial blood pressure; hypotension; hepatic dysfunction; vasodilation; nitric oxide; portal hypertension; systemic circulationAbstract
Viral hepatitis is a widespread infectious disease affecting the liver parenchyma
and leading to systemic metabolic and hemodynamic disturbances. Although hepatic
injury is primarily associated with abnormalities in bilirubin metabolism, coagulation,
and inflammation, alterations in arterial blood pressure (BP) remain under
investigated. This study aims to assess arterial BP changes in patients with acute and
chronic viral hepatitis, evaluate contributing mechanisms, and identify clinical
correlations with liver dysfunction. A total of 120 patients were examined and divided
into hepatitis A, B, and C groups. Blood pressure, biochemical parameters (ALT, AST,
bilirubin), and markers of hepatic synthetic function were recorded. Results
demonstrated a significant trend toward reduced systolic and diastolic BP in moderate
and severe hepatitis, whereas mild hepatitis showed stable or slightly increased BP
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