“THE MECHANISM OF THE INFLUENCE OF THE NASOPHARYNGEAL MICROBIOTA IN THE DEVELOPMENT OF ANTIBIOTIC SUSCEPTIBILITY IN CHILDREN.”
Keywords:
children, adverse drug reactions, modeling, drug safety. «Алгоритм влияния назофарингеальной микробиоты на формирование чувствительности к антибиотикам у детей».Abstract
The use of antibiotics in children - in most cases - is confirmed by
extrapolation of data obtained from clinical trials in adult populations. This puts
children at higher risk of developing adverse drug reactions due to off-label drug use
and dosage issues. The main types of adverse reactions are drug hypersensitivity
reactions, an idiosyncratic type of adverse reaction that is largely unpredictable and
can cause high morbidity and mortality in a difficult to identify specific patient
population. The lack of complete understanding of the pathophysiology of DHRs and
their unpredictable nature make them problematic in clinical practice and drug
development.
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