CLINICAL AND LABORATORY SIGNIFICANCE OF SYSTEMIC INFLAMMATORY MARKERS IN VARIOUS FORMS OF BRUCELLOSIS AND OPTIMIZATION OF TREATMENT
Keywords:
Keywords: brucellosis, systemic inflammation, biomarkers, C-reactive protein, cytokines, diagnosis, treatment.Abstract
Abstract
Brucellosis remains a significant zoonotic infection worldwide, characterized by
a wide spectrum of clinical manifestations and a tendency toward chronicity. Systemic
inflammatory response plays a key role in the pathogenesis and clinical course of the
disease. This article analyzes the clinical and laboratory significance of systemic
inflammatory markers in different clinical forms of brucellosis and discusses
approaches to optimizing treatment strategies based on these markers. Assessment of
inflammatory biomarkers allows for improved early diagnosis, evaluation of disease
severity, monitoring of therapeutic effectiveness, and prevention of complications.
References
References:
1. World Health Organization. Brucellosis in humans and animals. WHO Press;
Geneva, 2006.
2. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global
map of human brucellosis. Lancet Infect Dis. 2006;6(2):91–99.
3. Franco MP, Mulder M, Gilman RH, Smits HL. Human brucellosis. Lancet Infect
Dis. 2007;7(12):775–786.
4. Corbel MJ. Brucellosis: an overview. Emerg Infect Dis. 1997;3(2):213–221.
5. Seleem MN, Boyle SM, Sriranganathan N. Brucellosis: a re-emerging zoonosis. Vet
Microbiol. 2010;140(3–4):392–398.
6. Skalsky K, Yahav D, Bishara J, et al. Treatment of human brucellosis: systematic
review and meta-analysis of randomised controlled trials. BMJ.
2008;336(7646):701–704.
7. Young EJ. An overview of human brucellosis. Clin Infect Dis. 1995;21(2):283–289.
8. Navarro-Martínez A, Solera J, Corredoira J, et al. Serum cytokine profile in patients
with acute and chronic brucellosis. Clin Exp Immunol. 2005;141(3):476–482.
9. Kazak E, Akalın H, Yılmaz E, et al. Evaluation of inflammatory markers in
brucellosis. Infection. 2016;44(4):453–460.
10. Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features
of human brucellosis. Indian J Med Microbiol. 2007;25(3):188–202.
