MIKROBIOTA VA INSON METABOLIZMI O‘RTASIDAGI BIOKIMYOVIY BOG‘LIQLIK
Keywords:
Kalit so‘zlar: Mikrobiota, Metabolizm, Qisqa zanjirli yog‘ kislotalari, Disbioz, Safro kislotalari, Insulin rezistentligi, Neyroplastiklik, Metabolik sindrom, Probiotiklar, MetagenomikaAbstract
Annotatsiya: Mazkur maqola ichak mikrobiotasi va inson metabolizmi
o‘rtasidagi murakkab biokimyoviy o‘zaro bog‘liqlikni tizimli tahlil qilishga
bag‘ishlangan. Ichak mikrobiotasi organizmda metabolik homeostazni saqlash,
energiya almashinuvi, lipid va uglevod metabolizmini tartibga solish, immun javobni
modulyatsiya qilish hamda neyroendokrin tizim faoliyatiga ta’sir ko‘rsatishda muhim
rol o‘ynaydi. Maqolada qisqa zanjirli yog‘ kislotalari (SCFA), safro kislotalari
metabolizmi, vitaminlar va aminokislotalar almashinuvi kabi asosiy mexanizmlar tahlil
qilinadi. Shuningdek, mikrobiota tarkibining o‘zgarishi (disbioz) va uning semizlik, 2-
tip qandli diabet, metabolik sindrom hamda jigar kasalliklari bilan bog‘liqligi ko‘rib
chiqiladi. Zamonaviy tadqiqot yo‘nalishlari - metagenomika, metabolomika, probiotik
va prebiotik terapiya, shuningdek fekal mikrobiota transplantatsiyasi (FMT)
istiqbollari yoritilgan. Maqola mikrobiota va metabolizm o‘rtasidagi molekulyar va
klinik bog‘liqlikni chuqurroq anglashga xizmat qiladi.
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