CHRONIC MYELOPROLIFERATIVE NEOPLASMS: A COMPREHENSIVE REVIEW
Keywords:
Keywords: myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, primary myelofibrosis, JAK2, CALR, MPL, hematologic malignancyAbstract
Abstract
Chronic myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem
cell disorders characterized by the overproduction of one or more types of blood cells.
These disorders are typically slow-progressing but may evolve into acute leukemia or
bone marrow failure over time. This review provides an in-depth discussion of the main
types of Ph-negative MPNs: polycythemia vera (PV), essential thrombocythemia (ET),
and primary myelofibrosis (PMF). It covers their clinical features, genetic mutations,
diagnostic criteria, treatment approaches, and prognosis.
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