DYNAMIC MORPHOLOGICAL CHANGES IN THE STOMACH IN THE CONTEXT OF ULCERATIVE COLITIS: AN EXPERIMENTAL STUDY
Keywords:
Keywords: stomach, ulcerative colitis, experiment, histology, morphometry, ratsAbstract
Abstract
This study comprehensively examined morphological and morphometric
changes in the gastric mucosa and wall under experimental ulcerative colitis (UC)
conditions. The experiment was conducted using an animal model in which colitis was
induced with TNBS. Histological examinations revealed severe dystrophic,
inflammatory, erosive, and necrotic changes in the gastric mucosa, vascular and
cellular infiltration in the submucosa, and degenerative processes in the muscular layer.
These changes significantly impact the structural and functional state of the gastric
wall. The results have practical significance for clinical gastroenterology and
morphology.
References
References
1. Baker D.E., et al. Experimental models of inflammatory bowel disease:
relevance to human IBD. Toxicol Pathol. 2015; 43(4): 545–563.
2. Neurath M.F. Cytokines in inflammatory bowel disease. Nat Rev Immunol.
2014; 14(5): 329–342.
3. Wirtz S., Neufert C., Weigmann B., Neurath M.F. Chemically induced mouse
models of intestinal inflammation. Nat Protoc. 2007; 2(3): 541–546.
4. Zhou Q., Zhang B., Verne G.N. Intestinal permeability and bacterial
translocation in IBS and IBD. Neurogastroenterol Motil. 2009; 21(6): 403–412.
5. Abdulxamidova M., Abdurahmanova D.R. Morphological evaluation of gastric
changes in inflammatory bowel syndrome: an experimental study. Updates in
Medicine. 2023; 1(4): 35–40.
6. Ghosh S., Mitchell R. Impact of inflammation on gastric epithelium: from
molecular changes to mucosal damage. Clin Sci (Lond). 2020; 134(7): 833–850.
7. Lazaranko L.L., Jumaniyozova S.M. Basics of morphological diagnostics.
Tashkent: Medical Publishing House, 2022.
8. Kumar V., Abbas A., Aster J. Robbins and Cotran Pathologic Basis of Disease.
10th ed. Philadelphia: Elsevier; 2021.
9. Aliev A.A., Ismoilova D.M. Gastric gland status in colitis models. Practical
Morphology Journal. 2024; 2(1): 22–27.
10. Matsumoto S., et al. Role of mast cells in the pathogenesis of inflammatory
bowel disease. J Gastroenterol. 2010; 45(8): 840–849.
11. Tolibova Z.R., Rashidova L.K. Histomorphological assessment of the stomach
in TNBS-induced colitis. Uzbek Medical Journal. 2023; 2(3): 89–94.
12. Ghoshal U.C. et al. Role of nitric oxide in gastrointestinal inflammation. Indian
J Gastroenterol. 2017; 36(6): 439–449.
13. Hanauer S.B. Inflammatory bowel disease: epidemiology, pathogenesis, and
therapeutic opportunities. Inflamm Bowel Dis. 2006; 12(Suppl 1): S3–S9.
14. Haque M., et al. Gastrointestinal histopathology in animal models of colitis.
Histol Histopathol. 2020; 35(5): 481–490.
15. Abdullayeva G., Umarova S.T. Modeling GI inflammation in rats:
morphological changes. Bulletin of Biological Sciences. 2024; 2(1): 63–68.
