IMMOBILIZATSION STRESSDA LYUTEOLIN FLAVONOIDINING OQ KALAMUSHLARDA TURLI A'ZOLARDA LIPIDLARNING PEREKISLI OKSIDLANISHIGA TA'SIRI
Keywords:
Kalit so'zlar: lyuteolin, malondialdegid (MDA), immobilizatsion stress, lipidlarning perekisli oksidlanishi (LPO), oksidativ stress, flavonoid, antioksidant, jigar, yurak, buyrak, muskullar, oshqozon osti bezi.Abstract
ANNOTATSIYA
Ushbu maqolada immobilizatsion stress sharoitida lyuteolin flavonoidining oq
kalamushlarda jigar, oshqozon osti bezi, buyrak, yurak va muskullarda
malondialdegid (MDA) hosil bo'lishiga ta'siri o'rganildi. Tajribalar uch guruhda:
nazorat, immobilizatsion stress va lyuteolin (50 mg/kg) guruhlarida olib borildi. In
vivo tajribalarda lyuteolin 50 mg/kg dozasi barcha o'rganilgan a'zolarda lipidlarning
perekisli oksidlanishini (LPO) sezilarli darajada ingibirlashi aniqlandi. Olingan
natijalar lyuteolinning keng spektrli antioksidant ta'sirini va immobilizatsion stress
korreksiyasida samarali himoya modda sifatida qo'llanilishi mumkinligini ko'rsatadi.
References
FOYDALANILGAN ADABIYOTLAR
1. Asrarov M.I., Komilov E.Dj., Ergashev N.A. i dr. Mexanizm deystviya flavona
lyuteolina na funktsii mitoxondriy pecheni krыs // Vopr. biol. med. i farm. ximii. -
2015. - No12. - S. 38-43.
2. Armstrong J.S. Mitochondrial medicine: pharmacological targeting of
mitochondria in disease // British J. Pharmacology. - 2007. - Vol. 151. - P. 1154-
1165.
3. Cory H., Passarelli S., Szeto J. et al. The role of polyphenols in human health and
food systems: a mini-review // Front Nutr. - 2018. - Vol. 5. - P. 87.
4. Duchen M.R. Roles of Mitochondria in Health and Disease // Diabetes. - 2004. - V.
53. - P. S96-S102.
5. Juravlyova L.V., Krivonosova E.M. Sravnitelnaya xarakteristika
gepatoprotektornyx sredstv // Suchasna gastroenterologiya. - 2013. - No4(72). - S.
93-101.
6. Panickar K.S., Anderson R.A. Mechanisms underlying the protective effects of
myricetin and quercetin following oxygen-glucose deprivation // Neuroscience. -
2011. - Vol. 183. - P. 1-14.
7. Potapovich A.I., Kostyuk V.A. Sravnitelnoe issledovanie antioksidantnyx svoystv
i sitoprotektornoy aktivnosti flavonoidov // Bioximiya. - 2003. - T.68(5). - S. 632-
638.
8. Ramkumar K.M. et al. Protective effect of gallic acid on alloxan-induced oxidative
stress in rats // Hum Exp Toxicol. - 2014. - Vol.33(6). - P. 638-649.
9. Skulachev V.P. Bioenergetika. Membrannye preobrazovateli energii. - M.:
Vysshaya shkola, 1989. - 271 s.
10. Stalnaya I.D., Garishvili T.G. Metod opredeleniya malonovogo dialdegida s
pomoshchyu tiobarbiturovoy kisloty // Sovremennye metody v bioximii. - M., 1977.
- S. 66-68.
11. Zinoveva V.N., Spasov A.A. Mexanizmy antikancerogennyx effektov rastitelnyx
polifenolov // Biomeditsinskaya ximiya. - 2012. - T.58(3). - S. 257-271.
12. Shilov A.M., Melnik M.V., Chubarov M.V. Kompleksnye antioksidanty v
profilaktike i lechenii zabolevaniy serdechno-sosudistoy sistemy // Rossiyskie
meditsinskie vesti - 2004. - No4. - S. 45-49.
