MORPHOMETRIC PARAMETERS OF THE SPLEEN IN THE EARLY ANTENATAL PERIOD OF DEVELOPMENT
Keywords:
Key words: spleen, antenatal period, splenic morphometry, lymphoid organ, hematopoiesis, fetal development, white pulp, red pulp.Abstract
Abstract. In the study of spleen specimens from embryos and fetuses, at the 5th–
6th week a primary splenic rudiment was identified within the dorsal mesogastrium.
By weeks 8–9, distinct red and white pulp precursors became recognizable, with early
lymphocyte populations appearing in the periarteriolar sheaths. By weeks 11–12, the
spleen demonstrated well-formed trabecular framework, sinusoidal vasculature, and
primary lymphoid follicles. Two peaks of active lymphocyte proliferation were
established: at 18–20 weeks and at 27–28 weeks of embryogenesis, coinciding with
intensification of extramedullary hematopoiesis and expansion of the white pulp
compartment.
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