IN VIVO EVALUATION OF CHITOSAN–TRICALCIUM PHOSPHATE BIOACTIVE COATING FOR ENHANCED OSSEOINTEGRATION OF TITANIUM DENTAL IMPLANTS
Keywords:
Keywords: dental implants, bioactive coating, chitosan, tricalcium phosphate, osseointegration, biomaterialsAbstract
Abstract
The increasing prevalence of partial and complete edentulism necessitates the
development of advanced implant systems capable of improving osseointegration and
long-term clinical outcomes. Surface modification of titanium implants using bioactive
materials represents a promising strategy for enhancing biological integration.This
study aimed to experimentally evaluate the osteointegrative effectiveness and
biocompatibility of a novel bioactive coating based on tricalcium phosphate and
chitosan for domestically manufactured dental implants.An in vivo experimental study
was conducted using 72 chinchilla rabbits divided into three groups: commercial
implants, uncoated domestic titanium implants, and domestic implants coated with a
bioactive polymer matrix. Radiological, densitometric, histomorphological, and
biochemical analyses were performed at different postoperative periods.The developed
coating demonstrated nanoscale morphology and stable adhesion to titanium surfaces.
Experimental implants with bioactive coating exhibited accelerated bone regeneration,
increased peri-implant bone density, and improved trabecular organization compared
with uncoated implants. Positive osteointegration dynamics became evident after the
first postoperative month.
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