FERMENTATSIYA SHAROITLARINING POSTBIOTIK METABOLITLAR TARKIBI VA BIOLOGIK FAOLLIGIGA TA'SIRI
Keywords:
Kalit so‘zlar: Fermentatsiya sharoitlari, postbiotik metabolitlar, probiotiklar, qisqa zanjirli yog‘ kislotalari (SCFA), bakteriosinlar, ekzopolisaxaridlar (EPS), Lactobacillus, Bifidobacterium, antimikrobiyal faollik, immunomodulyatsiya, antioksidant, qattiq fazali fermentatsiya, suyuq fazali fermentatsiya, biologik faollik, metabolomika, farmatsevtika.Abstract
Annotatsiya
Fermentatsiya sharoitlari postbiotik metabolitlarning tarkibi va biologik
faolligiga sezilarli ta’sir ko‘rsatadi. Postbiotiklar – probiotik mikroorganizmlar
(masalan, Lactobacillus va Bifidobacterium turlarining) fermentatsiya jarayonida
ishlab chiqaradigan o‘lik hujayralar, ularning komponentlari va metabolitlari (SCFA,
bakteriosinlar, EPS va boshqalar) bo‘lib, ular jonli hujayralarsiz ham sog‘liq uchun
foydali ta’sir ko‘rsatadi. Ushbu maqolada fermentatsiya parametrlari (harorat, pH, oziq
muhit tarkibi, vaqt, kislorod darajasi) metabolitlar hosildorligi va faolligiga qanday
ta’sir etishi tahlil qilinadi. Optimal sharoitlarda (masalan, 37°C, pH 5.5–6.5) SCFA va
bakteriosinlar miqdori ortadi, bu esa antimikrobiyal, immunomodulyator va
antioksidant xususiyatlarni kuchaytiradi.
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